刘瑞田
研究员
- 学历/学位: 研究生学历/博士学位
- 研究方向: 生物技术药物
- 邮箱: rtliu@ipe.ac.cn
- 地址: 北京市海淀区中关村北二街1号
- 邮编: 100190
- 课题组网站:
简历介绍
刘瑞田，研究员、博士生导师，中国科学院过程工程研究所生物药物工程研究部主任，课题组长。1998年毕业于山东大学获博士学位，次年留校任教；2002-2005年在美国亚利桑那州立大学从事博士后研究；2005-2012年在清华大学工作；2012年-今在中国科学院过程工程研究所工作。长期从事治疗重大疾病的生物技术药物的研究。目前主要致力于治疗阿尔茨海默病、帕金森病和肿瘤等的基因工程抗体、疫苗、多肽及纳米药物及神经退行性疾病发病机理研究。为国家科技重大专项“十二五”、“十三五”重大新药创制专项责任专家，国家重点研发计划“蛋白质机器及生命调控”重点专项总体组专家，曾担任j alzheimers dis等科技期刊副主编。先后主持国家科技重大专项、863计划课题、中科院先导专项和国家自然基金等10余项国家级科研项目。在nano today、 adv func mater、biomaterials、brit j pharmacol、cell reports, acs appl mater interfaces等国际著名期刊发表论文80多篇，申请或获得国内外专利22项，2种i类新药处于中试研究中。
代表论著
1. shuai lu, xi-xiu xie, lei zhao, bin wang, jie zhu, ting-rui yang, guang-wen yang, mei ji, cui-ping lv, jian xue, er-hei dai, xi-ming fu, dong-qun liu, lun zhang, sheng-jie hou, xiao-lin yu, yu-ling wang, hui-xia gao, xue-han shi, chang-wen ke, bi-xia ke, chun-guo jiang*, rui-tian liu*. the immunodominant and neutralization linear epitopes for sars-cov-2. cell reports. 2021, 34:108666.
2. ling-xiao zhang, ying-bo jia, ya-ru huang, hui-na liu, xia-mei sun, ting cai*, rui-tian liu*, and zhi ping xu*. efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma. nano research, 2021, 14:1326-1334.
3. ling-xiao zhang, ying-bo jia, xia-mei sun, xiao-ge liu, mingdong dong, zhiping xu*, rui-tian liu*. nanovaccine’s rapid induction of anti-tumor immunity significantly improves malignant cancer immunotherapy. nano today. 2020, 35:100923.
4. lun zhang, xiao-ge liu, dong-qun liu, xiao-lin yu, ling-xiao zhang, jie zhu, shuai lu*, rui-tian liu*. a conditionally releasable “don’t eat me” cd47 signal facilitates microglia-targeted drug delivery for the treatment of alzheimer's disease. advanced functional materials. 2020, 30:1910691.
5. mei ji, xi-xiu xie, dong-qun liu, shuai lu, ling-xiao zhang, ya-ru huang, rui-tian liu*. engineered hepatitis b core virus-like particle carrier for precise and personalized alzheimer’s disease vaccines via spycatcher/spytag technology. applied materials today. 2020, 19:100575.
6. xiao-lin yu, jie zhu, xiang-meng liu, peng-xin xu, yue zhang, rui-tian liu*. vaccines targeting the primary amino acid sequence and conformational epitope of amyloid- had distinct effects on neuropathology and cognitive deficits in eae/ad mice. br j pharmacol. 2020, 177:2860-2871.
7. ya-ru huang, xi-xiu xie, mei ji, xiao-lin yu, jie zhu, ling-xiao zhang, xiao-ge liu, wei c, gang li*, rui-tian liu*. naturally occurring autoantibodies against -synuclein rescues memory and motor deficits and attenuates -synuclein pathology in mouse model of parkinson's disease. neurobiol dis. 2019, 124:202-217.
8. mei ji, xi-xiu xie, dong-qun liu, xiao-lin yu, yue zhang, ling-xiao zhang, shao-wei wang, ya-ru huang, rui-tian liu*. hepatitis b core vlp-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in tau.p301s mouse model of alzheimer's disease and frontotemporal dementia. alzheimers res ther. 2018, 10(1):55.
9. dong-qun liu, shuai lu, ling-xiao zhang, mei ji, shu-ying liu, shao-wei wang, rui-tian liu*. an indoleamine 2, 3-dioxygenase sirna nanoparticle-coated and trp2-displayed recombinant yeast vaccine inhibits melanoma tumor growth in mice. j control release. 2018, 273:1-12.
10. ling-xiao zhang, xi-xiu xie, dong-qun liu, zhiping xu*, rui-tian liu*. efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy. biomaterials. 2018, 174:54-66.