研究员-凯发网

张松平，研究员，博士生导师，课题组长，中国科学院过程工程研究所生物医药研究部主任。先后于1998年和2002年获得天津大学学士和博士学位。博士论文曾荣获“全国百篇优秀博士论文提名奖”。2002-2004年瑞典lund大学博士后，2005年1月加入中科院过程所生化工程国家重点实验室。研究方向是生物医药工程，近期重点以mrna、蛋白质药物、重组病毒样颗粒/病毒载体等生物大分子药物为研究对象，聚集其制备和应用过程中的结构稳定和活性保持，开展分子设计、精准合成、抗失活纯化与组装、以及新型递送系统的研究，以此发展生物大分子药物先进制备过程和理论。

目前已在生物催化、生物分离、生物药制剂等领域发表论文150余篇，申请发明专利40余项，多项成果获得实施应用。建立的灭活口蹄疫病毒抗原含量快速、定量检测技术，被国家农业部推荐为试行检测标准在疫苗生产企业应用。兼任国家农业部兽药评审专家，cde特别聘请的疫苗评审咨询专家，《j chromatography a》、《biochemical engineering j》和《biotech notes》编委。

1. lin xuan, su zhiguo, ma guanghui, zhang songping*: separation of bio-particles by ion-exchange chromatography. in: nesterenko pn, poole cf, sun y (eds.): handbooks of separation science: ion-exchange chromatography and related techniques, 2024, elsevier, amsterdam, netherlands, pp 553-578. (book chapter)

2. feng xue, su zhiguo, cheng yuan, ma guanghui, zhang songping*. messenger rna chromatographic purification: advances and challenges. j chromatography a, 2023, 1707: 464321 (invited review)

3. che shiyi, feng xue, li zhengjun, su zhiguo, ma guanghui, li zhikao, yu aibing, liu minsu*, zhang songping*. on-column capping of poly dt media-tethered mrna accomplishes high capping efficiency, enhanced mrna recovery, and improved stability against rnase. biotechnol bioeng. 2023, doi: 10.1002/bit.28560

4. luo hong, ma yanyan, ren ying, li zhengjun, sheng yanan, wang yingli, suz higuo, bi jingxiu*, zhang songping*. study of self-assembling properties of hbc-vlp derivatives aided by molecular dynamic simulations from a thermodynamic perspective, journal of biomolecular structure & dynamics, 2023, doi: 10.1080/07391102.2023.2273438

5. li zhenjun, ma yanyan, ren ying, lin xuan, su zhiguo, zhang songping*. thermal-triggered loading and gsh-responsive releasing property of hbc particles for drug delivery. journal of controlled release. 2023, 362:784-796

6. lin xuan, sheng yanan, zhang xuan, li zhengjun, yang yanli, wu jie, su zhiguo, ma guanghui, zhang songping*. oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine. journal of controlled release,2022, 346:380–391.

7. lu fengying, li zhegnjun, sheng yanan, ma yanyan, yang yanli, ren ying, su zhiguo, yu rong*, zhang songping*. thermal-triggered packing of lipophilic nir dye ir780 in hepatitis b core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy. biomaterials, 2021, 276: 121035

8. lin xuan, yang yanli, song yanmin, li shuai, zhang xuan, su zhiguo*, zhang songping*. a possible action of divalent transition metal ions at the interpentameric interface of inactivated foot-and-mouth disease virus provides a simple but effective approach to enhance stability. journal of virology, 2021, 95: e02431-20

9. song yanmin, yang yanli*, lin xuan, zhao qizu, li zhengjun, ma guanghui, su zhiguo, zhang songping*. on-line separation and quantification of virus antigens of different serotypes in multivalent vaccines by capillary zone electrophoresis: a case study for quality control of foot-and-mouth disease virus vaccines. j chromatography a. 2021, 1637: 461834

10. wei jiangxue, li zhengjun, yang yanli, ma guanghui, su zhiguo*, zhang songping*. an apoferritin-haemagglutinin conjugate vaccine with encapsulated nucleoprotein antigen peptide from influenza virus confers enhanced cross protection. bioconjugate chemistry, 2020, 31: 1948-1959